CTBS

Across TCGA cell cohorts, CTBS mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTBS-associated genes across cancer lineages are FAM153CP, TSGA13, and SMIM18. Each is linked with CTBS in more than 1 cancer types. Because this analysis shows association rather than direction, both CTBS-to-partner and partner-to-CTBS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM153CP grouped by CTBS-low versus CTBS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBS→partner) and Y-score (partner→CTBS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM153CP →	+0.442	+3.539	<.001	.004	3	1
LARGE_INTESTINE	TSGA13 →	+0.177	+2.994	.002	.006	3	1
LARGE_INTESTINE	SMIM18 →	+0.134	+3.468	.004	.007	3	1
BLOOD_Leukemia	SNTN →	+0.038	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FAM153CP by CTBS expression — LARGE_INTESTINE

Explore this box plot interactively →