CTBP2

Across TCGA patient cohorts, CTBP2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTBP2-associated genes across cancer lineages are PDCD4, Caspase-7-cleavedD198, and ERK2. Each is linked with CTBP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CTBP2-to-partner and partner-to-CTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CTBP2-low versus CTBP2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBP2→partner) and Y-score (partner→CTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PDCD4 →	-0.430	-3.000	.048	.034	3	3
STAD	Caspase-7-cleavedD198 →	+1.047	+3.000	.004	.034	3	3
UCEC	ERK2 →	+0.260	+2.146	<.001	<.001	3	3
COAD	ATM →	-0.583	-2.991	.003	.036	3	3
STAD	Akt_pS473 →	-0.399	-3.000	.041	.033	3	2
STAD	p38-MAPK_pT180_Y182 →	-0.570	-3.169	.001	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

PDCD4 by CTBP2 expression — STAD

Explore this box plot interactively →