CTBP2

Across TCGA cell cohorts, CTBP2 mutation is significantly associated with the RNA expression of many other genes, with 345 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTBP2-associated genes across cancer lineages are OBP2B, EIF3L, and SAMM50. Each is linked with CTBP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTBP2-to-partner and partner-to-CTBP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OBP2B grouped by CTBP2-low versus CTBP2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBP2→partner) and Y-score (partner→CTBP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OBP2B →	+0.297	+4.450	<.001	.004	3	1
LARGE_INTESTINE	EIF3L →	+0.572	+3.067	.001	.009	3	1
LARGE_INTESTINE	SAMM50 →	+0.510	+3.082	.004	.007	3	1
LARGE_INTESTINE	TRMU →	+0.657	+3.364	<.001	.002	3	1
LARGE_INTESTINE	HM13 →	-0.648	-3.321	<.001	.003	3	1
LARGE_INTESTINE	ACOT8 →	-0.638	-3.169	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 345 associations by consensus.

OBP2B by CTBP2 expression — OVARY

Explore this box plot interactively →