CSTL1

Across TCGA pan-cancer cohorts, CSTL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CSTL1 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CSTL1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CSTL1 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

HNSC, GBM, and OV are the cancer types where CSTL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.363	1.000	.049	10	view →
GBM	OS	Median	All	0.522	0.304	.016	9	view →
OV	DFS	Median	All	0.589	1.000	.034	4	view →
LSCC	OS	Quartile	II,III,IV	0.314	0.903	.012	4	view →
UCEC	OS	Tertile	All	1.000	0.896	.046	2	view →
LUAD	DFS	Median	All	0.285	0.708	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CSTL1–HNSC (DFS)

Open the HNSC breakdown →