CSTL1

Across TCGA patient cohorts, CSTL1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTL1-associated genes across cancer lineages are PCNA, RBM15, and STAT3_pY705. Each is linked with CSTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTL1-to-partner and partner-to-CSTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CSTL1-low versus CSTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTL1→partner) and Y-score (partner→CSTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.383	+2.321	<.001	.035	3	1
UCEC	RBM15 →	+0.350	+2.335	.029	.020	3	1
UCEC	STAT3_pY705 →	-0.490	-3.159	<.001	.019	3	1
UCEC	Bap1-c-4 →	+0.264	+3.189	.016	.010	3	1
UCEC	BRD4 →	+0.314	+2.329	.019	.020	3	1
UCEC	C-Raf →	+0.174	+2.321	.015	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PCNA by CSTL1 expression — UCEC

Explore this box plot interactively →