CSTF3

Across TCGA patient cohorts, CSTF3 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTF3-associated genes across cancer lineages are PDCD4, Rad50, and Caspase-7-cleavedD198. Each is linked with CSTF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTF3-to-partner and partner-to-CSTF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by CSTF3-low versus CSTF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTF3→partner) and Y-score (partner→CSTF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.331	-1.362	.047	.037	3	2
UCEC	Rad50 →	-0.176	-2.000	.040	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.720	+2.392	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.217	-2.000	.014	.009	3	1
UCEC	EGFR_pY1173 →	+0.062	+2.026	.027	.001	3	1
UCEC	A-Raf_pS299 →	-0.126	-2.584	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PDCD4 by CSTF3 expression — UCEC

Explore this box plot interactively →