CSTF2

Across TCGA patient cohorts, CSTF2 mutation is significantly associated with the RNA expression of many other genes, with 3,126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTF2-associated genes across cancer lineages are HSBP1P2, TRIM51FP, and TRIM64EP. Each is linked with CSTF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CSTF2-to-partner and partner-to-CSTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSBP1P2 grouped by CSTF2-low versus CSTF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTF2→partner) and Y-score (partner→CSTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSBP1P2 →	+0.381	+1.763	.002	.004	3	3
CESC	TRIM51FP →	+1.328	+4.539	<.001	.008	3	2
CESC	TRIM64EP →	+0.068	+6.554	<.001	<.001	3	2
CESC	PSAT1P4 →	+0.131	+4.503	<.001	.005	3	2
LUAD	RNU6-35P →	+0.735	+3.590	.005	.009	3	2
UCEC	PPP6R1 →	+0.430	+1.970	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,126 associations by consensus.

HSBP1P2 by CSTF2 expression — UCEC

Explore this box plot interactively →