CSTF2

Across TCGA patient cohorts, CSTF2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTF2-associated genes across cancer lineages are GATA3, 4E-BP1, and 14-3-3_beta. Each is linked with CSTF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTF2-to-partner and partner-to-CSTF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA3 grouped by CSTF2-low versus CSTF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTF2→partner) and Y-score (partner→CSTF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA3 →	+0.142	+1.453	.029	.015	3	2
UCEC	4E-BP1 →	+0.276	+2.145	.003	.009	3	2
UCEC	14-3-3_beta →	-0.083	-3.432	.017	.005	3	1
UCEC	eEF2 →	+0.388	+3.700	.001	.001	3	1
UCEC	EGFR_pY1068 →	-0.263	-2.584	.002	.001	3	1
UCEC	A-Raf_pS299 →	-0.110	-3.087	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

GATA3 by CSTF2 expression — UCEC

Explore this box plot interactively →