CSTF1

Across TCGA pan-cancer cohorts, CSTF1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CSTF1 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CSTF1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CSTF1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where CSTF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	II,III,IV	0.924	0.608	.013	22	view →
PDAC	DFS	Tertile	All	0.865	0.670	.016	4	view →
GBM	DFS	Median	All	0.462	0.283	.044	2	view →
LSCC	OS	Tertile	All	1.000	0.927	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CSTF1–LUAD (DFS)

Open the LUAD breakdown →