CSTF1

Across TCGA patient cohorts, CSTF1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTF1-associated genes across cancer lineages are ATM, Cyclin-B1, and EGFR_pY1068. Each is linked with CSTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTF1-to-partner and partner-to-CSTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CSTF1-low versus CSTF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTF1→partner) and Y-score (partner→CSTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.608	-2.459	.001	.019	3	2
UCEC	Cyclin-B1 →	+0.504	+1.700	.034	.044	3	2
UCEC	EGFR_pY1068 →	-0.268	-2.222	.011	.011	3	1
UCEC	INPP4B →	-0.274	-3.321	.046	.009	3	1
UCEC	Ku80 →	+0.219	+2.235	.028	.006	3	1
UCEC	MEK1 →	+0.384	+2.906	.013	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by CSTF1 expression — UCEC

Explore this box plot interactively →