CSTF1

Across TCGA cell cohorts, CSTF1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CSTF1-associated genes across cancer lineages are PLCZ1, MAGEL2, and PSKH2. Each is linked with CSTF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTF1-to-partner and partner-to-CSTF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLCZ1 grouped by CSTF1-low versus CSTF1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTF1→partner) and Y-score (partner→CSTF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PLCZ1 →	+0.152	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	MAGEL2 →	+0.029	+5.643	<.001	.002	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.021	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10C1 →	+0.066	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR12D1 →	+0.042	+4.887	<.001	.009	3	1
LARGE_INTESTINE	HOXB1 →	+0.021	+3.617	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PLCZ1 by CSTF1 expression — BLOOD_Lymphoma

Explore this box plot interactively →