CSTA

Across TCGA patient cohorts, CSTA protein abundance is significantly associated with the RNA expression of many other genes, with 20,692 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CSTA-associated genes across cancer lineages are IL1RN, PI3, and APOBEC3A. Each is linked with CSTA in more than 7 cancer types. Because this analysis shows association rather than direction, both CSTA-to-partner and partner-to-CSTA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CSTA versus IL1RN in COAD, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTA→partner) and Y-score (partner→CSTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IL1RN →	+1.839	+1.305	<.001	<.001	3	8
HNSC	PI3 →	+3.451	+1.371	<.001	<.001	3	7
COAD	APOBEC3A →	+1.653	+1.499	<.001	<.001	3	7
LSCC	S100A8 →	+2.490	+0.938	<.001	<.001	3	7
HNSC	FARP1 →	-0.715	-0.967	<.001	<.001	3	7
HNSC	S100A12 →	+2.600	+1.274	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,692 associations by consensus.

CSTA vs IL1RN — COAD

Explore this scatter interactively →