CSTA

Across TCGA patient cohorts, CSTA mutation is significantly associated with the RNA expression of many other genes, with 70 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CSTA-associated genes across cancer lineages are RNU6-365P, MTND2P7, and FTH1P9. Each is linked with CSTA in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTA-to-partner and partner-to-CSTA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-365P grouped by CSTA-low versus CSTA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTA→partner) and Y-score (partner→CSTA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-365P →	+0.270	+7.930	<.001	.008	3	1
LUAD	MTND2P7 →	+0.053	+7.930	.009	.008	3	1
SKCM	FTH1P9 →	+0.046	+5.421	<.001	.001	3	1
SKCM	RNU6-711P →	+0.208	+3.292	<.001	.006	3	1
SKCM	TFAMP2 →	+0.043	+3.548	<.001	.001	3	1
SKCM	ELOCP31 →	+0.138	+2.807	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 70 associations by consensus.

RNU6-365P by CSTA expression — LUAD

Explore this box plot interactively →