CST9L

Across TCGA pan-cancer cohorts, CST9L RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated CST9L data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher CST9L RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CST9L expression acts as an unfavorable survival marker, although some lineages such as BRCA and OV show a favorable association.

BRCA, DLBC, and KIRC are the cancer types where CST9L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	III,IV	0.937	0.820	<.001	92	view →
DLBC	OS	Tertile	II,III,IV	0.159	0.801	.001	82	view →
KIRC	DFS	Tertile	All	0.615	0.814	.002	57	view →
READ	OS	Tertile	II,III,IV	0.111	0.919	<.001	54	view →
COAD	OS	Tertile	IV	0.039	0.660	<.001	51	view →
TGCT	DFS	Tertile	III,IV	0.340	1.000	.002	36	view →
OV	OS	Median	All	0.888	0.812	.009	32	view →
MESO	OS	Tertile	III,IV	0.812	0.382	.037	24	view →
ACC	OS	Tertile	II,III,IV	0.288	0.801	.008	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
PAAD	OS	Tertile	II,III,IV	0.325	0.563	.012	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

CST9L–BRCA (DFS)

Open the BRCA breakdown →