CST8

Across TCGA pan-cancer cohorts, CST8 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated CST8 data layer compared with 15 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher CST8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CST8 expression acts as an unfavorable survival marker.

LIHC and BLCA are the cancer types where CST8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.015	0.784	<.001	12	view →
BLCA	OS	Median	All	0.188	0.687	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

CST8–LIHC (OS)

Open the LIHC breakdown →