CST8

Across TCGA patient cohorts, CST8 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,343 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CST8-associated GO terms across cancer lineages are Autocrine signaling, Regulation of reproductive process, and Transcription initiation at RNA polymerase I promoter. Each is linked with CST8 in more than 8 cancer types. Because this analysis shows association rather than direction, both CST8-to-partner and partner-to-CST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Autocrine signaling grouped by CST8-low versus CST8-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CST8→partner) and Y-score (partner→CST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Autocrine signaling →	+0.072	+0.154	<.001	.001	3	9
STAD	Regulation of reproductive process →	+0.040	+0.181	<.001	<.001	3	9
KIRP	Transcription initiation at RNA polymerase I promoter →	+0.060	+0.106	<.001	.004	3	8
STAD	Cellular response to oxygen levels →	+0.056	+0.167	<.001	<.001	3	8
STAD	Positive regulation of peptidase activity →	+0.057	+0.117	<.001	<.001	3	8
STAD	Ephrin receptor signaling pathway →	+0.058	+0.179	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,343 associations by consensus.

Autocrine signaling by CST8 expression — ESCA

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