CST8

Across TCGA patient cohorts, CST8 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CST8-associated genes across cancer lineages are Class-switched memory B-cells, Megakaryocytes, and Melanocytes. Each is linked with CST8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST8-to-partner and partner-to-CST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Class-switched memory B-cells grouped by CST8-low versus CST8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST8→partner) and Y-score (partner→CST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Class-switched memory B-cells →	-0.041	-2.578	.045	.011	3	1
SKCM	Megakaryocytes →	+0.034	+2.667	.002	.005	3	1
SKCM	Melanocytes →	+0.056	+2.195	.046	.032	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Class-switched memory B-cells by CST8 expression — SKCM

Explore this box plot interactively →