CST8

Across TCGA cell cohorts, CST8 RNA expression is significantly associated with the mutation status of many other genes, with 144 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CST8-associated genes across cancer lineages are IL27RA, HIRA, and SLC25A17. Each is linked with CST8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST8-to-partner and partner-to-CST8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL27RA grouped by CST8-low versus CST8-high in BLOOD_Leukemia.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST8→partner) and Y-score (partner→CST8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL27RA →	+3.969	+0.031	.009	<.001	3	2
BLOOD_Leukemia	HIRA →	+4.969	+0.046	.003	<.001	3	1
BLOOD_Leukemia	SLC25A17 →	+4.969	+0.046	.003	<.001	3	1
BLOOD_Leukemia	RUBCNL →	+4.384	+0.037	.006	<.001	3	1
BLOOD_Leukemia	FGF14 →	+4.969	+0.052	.003	<.001	3	1
BLOOD_Leukemia	MSLN →	+3.969	+0.031	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 144 associations by consensus.

IL27RA by CST8 expression — BLOOD_Leukemia

Explore this box plot interactively →