CST6

Across TCGA patient cohorts, CST6 protein abundance is significantly associated with the RNA expression of many other genes, with 10,379 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CST6-associated genes across cancer lineages are AREG, HELLS, and COL5A1. Each is linked with CST6 in more than 3 cancer types. Because this analysis shows association rather than direction, both CST6-to-partner and partner-to-CST6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CST6 versus AREG in LSCC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST6→partner) and Y-score (partner→CST6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AREG →	+2.020	+0.780	<.001	<.001	3	4
UCEC	HELLS →	-0.997	-1.071	<.001	<.001	3	4
BRCA	COL5A1 →	+1.173	+0.584	<.001	.004	3	4
BRCA	ADGRF4 →	+1.124	+0.720	<.001	.001	3	4
LSCC	RNASE7 →	+1.740	+0.614	<.001	.005	3	4
UCEC	RMI2 →	-0.893	-1.209	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,379 associations by consensus.

CST6 vs AREG — LSCC

Explore this scatter interactively →