CST4

Across TCGA pan-cancer cohorts, CST4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CST4 data layer compared with 21 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CST4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CST4 expression acts as an unfavorable survival marker, although some lineages such as LUSC show a favorable association.

LGG, UCEC, and LUSC are the cancer types where CST4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.238	0.799	<.001	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	All	0.868	0.384	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CST4–LGG (OS)

Open the LGG breakdown →