CST4

Across TCGA patient cohorts, CST4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,176 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CST4-associated genes across cancer lineages are CLDN1, LRRC25, and HLA-C. Each is linked with CST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST4-to-partner and partner-to-CST4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CST4 versus CLDN1 in UCEC, with a Pearson correlation of -0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST4→partner) and Y-score (partner→CST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLDN1 →	-2.304	-1.652	<.001	.006	3	2
BRCA	LRRC25 →	+1.378	+1.748	.001	.004	3	2
BRCA	HLA-C →	+1.451	+1.231	.002	.001	3	2
UCEC	ALKBH1 →	+0.218	+1.424	.007	.001	3	1
UCEC	ATP6V0A4 →	+1.786	+2.350	.005	.001	3	1
UCEC	HIBADH →	+0.731	+1.788	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,176 associations by consensus.

CST4 vs CLDN1 — UCEC

Explore this scatter interactively →