CST4

Across TCGA patient cohorts, CST4 mutation is significantly associated with the RNA expression of many other genes, with 767 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CST4-associated genes across cancer lineages are MIR4804, TRAJ27, and PSPC1P2. Each is linked with CST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST4-to-partner and partner-to-CST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4804 grouped by CST4-low versus CST4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST4→partner) and Y-score (partner→CST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4804 →	+0.303	+2.548	.004	.007	3	2
LUSC	TRAJ27 →	+0.515	+3.017	.001	.009	3	2
LUSC	PSPC1P2 →	+0.172	+4.776	<.001	<.001	3	2
SKCM	RN7SL300P →	+0.231	+3.940	<.001	.003	3	2
SKCM	MTND4LP1 →	+0.382	+3.893	<.001	.004	3	2
LUAD	AARS1P1 →	+0.069	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 767 associations by consensus.

MIR4804 by CST4 expression — UCEC

Explore this box plot interactively →