CST4

Across TCGA patient cohorts, CST4 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CST4-associated genes across cancer lineages are p62 Lck ligand, XBP1, and ATM. Each is linked with CST4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST4-to-partner and partner-to-CST4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by CST4-low versus CST4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST4→partner) and Y-score (partner→CST4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.374	+2.179	.013	.034	3	1
UCEC	XBP1 →	-0.191	-3.169	.003	.019	3	1
UCEC	ATM →	-0.472	-2.584	.025	.011	3	1
UCEC	Caspase-8 →	-0.321	-3.432	.006	.005	3	1
UCEC	CD49b →	-0.275	-2.986	.038	.035	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by CST4 expression — UCEC

Explore this box plot interactively →