CST2

Across TCGA patient cohorts, CST2 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CST2-associated genes across cancer lineages are naive B-cells, Adipocytes, and Hepatocytes. Each is linked with CST2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST2-to-partner and partner-to-CST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, naive B-cells grouped by CST2-low versus CST2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST2→partner) and Y-score (partner→CST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	naive B-cells →	+0.006	+4.217	.029	.014	3	1
UCEC	Adipocytes →	+0.020	+2.092	.007	.013	3	1
UCEC	Hepatocytes →	+0.010	+1.721	.017	.027	3	1
UCEC	pDC →	+0.051	+2.917	.013	.001	3	1
UCEC	Eosinophils →	+0.073	+3.048	.001	.018	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

naive B-cells by CST2 expression — LUAD

Explore this box plot interactively →