CST2

Across TCGA cell cohorts, CST2 RNA expression is significantly associated with the go_rna of many other GO terms, with 548 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CST2-associated GO terms across cancer lineages are Positive regulation of proteolysis, Glycolipid catabolic process, and Regulation of proteolysis. Each is linked with CST2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CST2-to-partner and partner-to-CST2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of proteolysis grouped by CST2-low versus CST2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CST2→partner) and Y-score (partner→CST2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of proteolysis →	+0.076	+1.380	<.001	.005	3	4
LUNG_NSCLC_LUAD	Glycolipid catabolic process →	+0.091	+0.771	.007	.006	3	4
LUNG_NSCLC_LUAD	Regulation of proteolysis →	+0.045	+1.074	.006	.002	3	4
LUNG_NSCLC_LUAD	Glycosaminoglycan catabolic process →	+0.112	+1.159	<.001	<.001	3	4
PANCREAS	Positive regulation of matrix metallopeptidase secretion →	-0.224	-1.456	<.001	.001	2	4
PANCREAS	Positive regulation of defense response to virus by host →	+0.059	+1.370	.006	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 548 associations by consensus.

Positive regulation of proteolysis by CST2 expression — PANCREAS

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