CST1

Across TCGA patient cohorts, CST1 mutation is significantly associated with the RNA expression of many other genes, with 664 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CST1-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and RNA5SP412. Each is linked with CST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST1-to-partner and partner-to-CST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by CST1-low versus CST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST1→partner) and Y-score (partner→CST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+0.987	+3.255	<.001	<.001	3	2
UCEC	RNA5SP411 →	+1.795	+2.393	<.001	.002	3	2
UCEC	RNA5SP412 →	+0.932	+2.967	<.001	<.001	3	2
UCEC	RNA5SP419 →	+1.198	+3.077	<.001	<.001	3	2
UCEC	RNA5SP410 →	+1.215	+3.204	<.001	<.001	3	2
UCEC	RNA5SP422 →	+1.387	+3.086	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 664 associations by consensus.

RNA5SP414 by CST1 expression — UCEC

Explore this box plot interactively →