CST1

Across TCGA patient cohorts, CST1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CST1-associated genes across cancer lineages are Bak, Ku80, and p38-MAPK_pT180_Y182. Each is linked with CST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST1-to-partner and partner-to-CST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bak grouped by CST1-low versus CST1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST1→partner) and Y-score (partner→CST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bak →	+0.282	+2.999	.019	.035	3	2
UCEC	Ku80 →	+0.304	+2.183	.007	.033	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.545	-3.169	.012	.019	3	1
UCEC	STAT3_pY705 →	-0.591	-3.584	<.001	.002	3	1
UCEC	VHL →	-1.281	-3.321	<.001	.010	3	1
UCEC	ATM →	-0.655	-2.986	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Bak by CST1 expression — UCEC

Explore this box plot interactively →