CST1

Across TCGA cell cohorts, CST1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CST1-associated genes across cancer lineages are OXT, DEFB135, and BPIFB6. Each is linked with CST1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CST1-to-partner and partner-to-CST1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by CST1-low versus CST1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST1→partner) and Y-score (partner→CST1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OXT →	+0.070	+4.977	<.001	.007	3	1
SKIN	DEFB135 →	+0.640	+5.415	<.001	.004	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	HTR1E →	+0.085	+3.930	<.001	.003	3	1
LARGE_INTESTINE	UTF1 →	+0.022	+4.217	<.001	.001	3	1
LARGE_INTESTINE	ADH1A →	+0.160	+3.920	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OXT by CST1 expression — SKIN

Explore this box plot interactively →