CSRP2

Across TCGA patient cohorts, CSRP2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSRP2-associated genes across cancer lineages are INPP4B, STAT3_pY705, and Tuberin_pT1462. Each is linked with CSRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSRP2-to-partner and partner-to-CSRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CSRP2-low versus CSRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSRP2→partner) and Y-score (partner→CSRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.384	-3.000	.030	.036	3	1
UCEC	STAT3_pY705 →	-0.481	-2.999	<.001	.035	3	1
UCEC	Tuberin_pT1462 →	+0.332	+3.169	.008	.020	3	1
UCEC	VHL →	-1.119	-3.000	.002	.036	3	1
UCEC	mTOR_pS2448 →	-0.198	-2.980	.015	.036	2	1
UCEC	EGFR_pY1068 →	-0.388	-3.169	.004	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

INPP4B by CSRP2 expression — UCEC

Explore this box plot interactively →