CSRP1

Across TCGA pan-cancer cohorts, CSRP1 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CSRP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CSRP1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CSRP1 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and LUAD are the cancer types where CSRP1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSRP1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.528	<.001	12	view →
COAD	Male	III,IV	−2.477	<.001	9	view →
LUAD	Male	III,IV	−1.006	<.001	9	view →
LSCC	Female	All	−1.431	<.001	8	view →
CCRCC	Male	III,IV	−0.941	<.001	8	view →
PDAC	Female	All	+0.773	<.001	7	view →
OV	All	All	−1.008	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CSRP1–HNSC

Open the HNSC breakdown →