CSRP1

Across TCGA patient cohorts, CSRP1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSRP1-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and CD31. Each is linked with CSRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSRP1-to-partner and partner-to-CSRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CSRP1-low versus CSRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSRP1→partner) and Y-score (partner→CSRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.151	+2.827	<.001	.035	3	1
UCEC	PCNA →	+0.255	+3.000	.041	.037	2	1
UCEC	CD31 →	+0.182	+2.817	.032	.036	2	1
UCEC	EGFR →	-0.184	-3.000	.046	.037	1	1
UCEC	Notch1 →	+0.206	+3.000	.011	.037	1	1
UCEC	Beclin →	+0.117	+3.000	.033	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Caspase-7-cleavedD198 by CSRP1 expression — UCEC

Explore this box plot interactively →