CSPP1

Across TCGA patient cohorts, CSPP1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSPP1-associated genes across cancer lineages are ERK2, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with CSPP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CSPP1-to-partner and partner-to-CSPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by CSPP1-low versus CSPP1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSPP1→partner) and Y-score (partner→CSPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ERK2 →	+0.352	+2.816	.029	.036	3	3
UCEC	Cyclin-B1 →	+0.559	+2.807	.001	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.698	+1.945	<.001	.002	3	3
UCEC	4E-BP1 →	+0.189	+1.807	.022	.024	3	3
LUAD	JNK_pT183_Y185 →	-0.140	-2.974	.032	.035	3	2
LUSC	p70-S6K →	+0.274	+2.816	.041	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ERK2 by CSPP1 expression — LUSC

Explore this box plot interactively →