CSPP1

Across TCGA cell cohorts, CSPP1 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CSPP1-associated genes across cancer lineages are EN1, NLRP8, and IL4. Each is linked with CSPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSPP1-to-partner and partner-to-CSPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EN1 grouped by CSPP1-low versus CSPP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSPP1→partner) and Y-score (partner→CSPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EN1 →	+0.248	+3.814	.003	.002	3	2
SKIN	NLRP8 →	+0.026	+4.977	<.001	.007	3	1
BLOOD_Leukemia	IL4 →	+1.863	+3.007	<.001	.007	3	1
BLOOD_Leukemia	BTBD16 →	+0.095	+4.544	<.001	<.001	3	1
BLOOD_Leukemia	SYT16 →	+0.133	+3.963	<.001	.001	3	1
BLOOD_Leukemia	CYP39A1 →	+0.098	+3.091	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

EN1 by CSPP1 expression — BLOOD_Leukemia

Explore this box plot interactively →