CSPG5

Across TCGA patient cohorts, CSPG5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSPG5-associated genes across cancer lineages are p27_pT198, eIF4E, and ACC1. Each is linked with CSPG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSPG5-to-partner and partner-to-CSPG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by CSPG5-low versus CSPG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSPG5→partner) and Y-score (partner→CSPG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.092	+2.115	.049	.019	3	2
UCEC	eIF4E →	+0.207	+2.820	.024	.035	3	1
UCEC	ACC1 →	+0.347	+2.820	.029	.035	3	1
UCEC	IGFBP2 →	-0.791	-2.115	.005	.019	3	1
UCEC	MEK1 →	+0.373	+3.000	.019	.036	3	1
UCEC	Notch1 →	+0.205	+2.115	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

p27_pT198 by CSPG5 expression — UCEC

Explore this box plot interactively →