CSPG4

Across TCGA pan-cancer cohorts, CSPG4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CSPG4 data layer compared with 29 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher CSPG4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CSPG4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where CSPG4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.884	1.000	.006	36	view →
CCRCC	DFS	Median	III,IV	0.962	0.768	.015	9	view →
LSCC	OS	Median	II,III,IV	0.882	1.000	.020	8	view →
HNSC	DFS	Median	All	0.978	0.906	.031	5	view →
GBM	DFS	Quartile	All	0.286	0.467	.029	2	view →
PDAC	DFS	Median	III,IV	0.460	0.852	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CSPG4–LUAD (OS)

Open the LUAD breakdown →