CSPG4

Across TCGA patient cohorts, CSPG4 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSPG4-associated genes across cancer lineages are MYH11, Cyclin-B1, and ATM. Each is linked with CSPG4 in more than 3 cancer types. Because this analysis shows association rather than direction, both CSPG4-to-partner and partner-to-CSPG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYH11 grouped by CSPG4-low versus CSPG4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSPG4→partner) and Y-score (partner→CSPG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MYH11 →	-1.328	-3.000	<.001	.035	3	4
LUAD	Cyclin-B1 →	+0.634	+3.000	.003	.035	3	4
UCEC	ATM →	-0.649	-2.169	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.716	+2.078	<.001	<.001	3	4
UCEC	JNK_pT183_Y185 →	-0.155	-2.000	<.001	<.001	3	3
LUSC	14-3-3_zeta →	+0.398	+2.367	.008	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

MYH11 by CSPG4 expression — LUAD

Explore this box plot interactively →