CSPG4

Across TCGA cell cohorts, CSPG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,877 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CSPG4-associated GO terms across cancer lineages are Positive regulation of focal adhesion assembly, Actin filament depolymerization, and Regulation of cell-substrate junction assembly. Each is linked with CSPG4 in more than 12 cancer types. Because this analysis shows association rather than direction, both CSPG4-to-partner and partner-to-CSPG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of focal adhesion assembly grouped by CSPG4-low versus CSPG4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CSPG4→partner) and Y-score (partner→CSPG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of focal adhesion assembly →	+0.199	+2.402	<.001	<.001	3	13
BONE	Actin filament depolymerization →	+0.229	+3.326	<.001	<.001	3	12
BONE	Regulation of cell-substrate junction assembly →	+0.163	+2.596	<.001	<.001	3	11
BONE	Positive regulation of stress fiber assembly →	+0.175	+2.917	<.001	<.001	3	11
BONE	Regulation of focal adhesion assembly →	+0.163	+2.596	<.001	<.001	3	11
BONE	Positive regulation of cell-substrate junction organization →	+0.169	+2.346	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,877 associations by consensus.

Positive regulation of focal adhesion assembly by CSPG4 expression — BONE

Explore this box plot interactively →