CSPG4

Across TCGA cell cohorts, CSPG4 mutation is significantly associated with the RNA expression of many other genes, with 1,881 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CSPG4-associated genes across cancer lineages are ELOA3DP, SLF2, and DCUN1D2. Each is linked with CSPG4 in more than 2 cancer types. Because this analysis shows association rather than direction, both CSPG4-to-partner and partner-to-CSPG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by CSPG4-low versus CSPG4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSPG4→partner) and Y-score (partner→CSPG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ELOA3DP →	+0.037	+3.906	<.001	.001	3	3
BLOOD_Leukemia	SLF2 →	+0.462	+3.228	.006	.004	3	3
BLOOD_Leukemia	DCUN1D2 →	+0.718	+3.643	<.001	<.001	3	3
LARGE_INTESTINE	TWNK →	+0.408	+2.000	.001	.009	3	3
LARGE_INTESTINE	S100PBP →	+0.615	+2.700	<.001	.001	3	3
LARGE_INTESTINE	DR1 →	+0.652	+2.584	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,881 associations by consensus.

ELOA3DP by CSPG4 expression — OESOPHAGUS

Explore this box plot interactively →