CSNK1G3

Across TCGA patient cohorts, CSNK1G3 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSNK1G3-associated genes across cancer lineages are GAPDH, ERK2, and MEK1. Each is linked with CSNK1G3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSNK1G3-to-partner and partner-to-CSNK1G3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by CSNK1G3-low versus CSNK1G3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSNK1G3→partner) and Y-score (partner→CSNK1G3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GAPDH →	+0.722	+2.815	.009	.036	3	2
UCEC	ERK2 →	+0.155	+1.247	.018	.045	3	2
UCEC	MEK1 →	+0.455	+3.807	<.001	<.001	3	2
UCEC	PDCD4 →	-0.615	-2.906	<.001	.001	3	2
UCEC	TFRC →	+0.694	+3.000	<.001	<.001	3	2
UCEC	ASNS →	+0.295	+2.222	.016	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

GAPDH by CSNK1G3 expression — COAD

Explore this box plot interactively →