CSNK1G2

Across TCGA pan-cancer cohorts, CSNK1G2 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CSNK1G2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CSNK1G2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CSNK1G2 is over-expressed in tumor, although a few such as HNSC and LSCC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where CSNK1G2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSNK1G2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	−0.711	<.001	8	view →
PDAC	All	II,III,IV	+0.862	.003	4	view →
LSCC	Male	All	−0.174	.016	2	view →
LUAD	All	All	−0.169	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CSNK1G2–HNSC

Open the HNSC breakdown →