CSNK1A1L

Across TCGA patient cohorts, CSNK1A1L mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSNK1A1L-associated genes across cancer lineages are Cyclin-B1, ATM, and Caspase-7-cleavedD198. Each is linked with CSNK1A1L in more than 2 cancer types. Because this analysis shows association rather than direction, both CSNK1A1L-to-partner and partner-to-CSNK1A1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CSNK1A1L-low versus CSNK1A1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSNK1A1L→partner) and Y-score (partner→CSNK1A1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.682	+3.459	.001	.005	3	3
UCEC	ATM →	-0.476	-1.986	.005	.029	3	3
UCEC	Caspase-7-cleavedD198 →	+0.771	+1.765	<.001	.014	3	3
COAD	FASN →	+0.416	+3.000	.006	.034	3	2
COAD	MEK1 →	+0.171	+1.610	.029	.042	3	2
COAD	MIG-6 →	+0.094	+1.644	.015	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Cyclin-B1 by CSNK1A1L expression — UCEC

Explore this box plot interactively →