CSNK1A1

Across TCGA patient cohorts, CSNK1A1 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSNK1A1-associated genes across cancer lineages are A-Raf_pS299, 14-3-3_beta, and eEF2. Each is linked with CSNK1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSNK1A1-to-partner and partner-to-CSNK1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by CSNK1A1-low versus CSNK1A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSNK1A1→partner) and Y-score (partner→CSNK1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.101	-1.678	.007	.021	3	2
UCEC	14-3-3_beta →	-0.069	-1.276	.031	.023	3	1
UCEC	eEF2 →	+0.383	+2.415	<.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.255	-2.058	.001	<.001	3	1
UCEC	eIF4G →	+0.252	+2.222	.011	.010	3	1
UCEC	ER-alpha →	-0.752	-2.058	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

A-Raf_pS299 by CSNK1A1 expression — UCEC

Explore this box plot interactively →