CSN2

Across TCGA patient cohorts, CSN2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,213 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible CSN2-associated GO terms across cancer lineages are Positive regulation of smoothened signaling pathway, Oligodendrocyte differentiation, and Positive regulation of neurogenesis. Each is linked with CSN2 in more than 7 cancer types. Because this analysis shows association rather than direction, both CSN2-to-partner and partner-to-CSN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of smoothened signaling pathway grouped by CSN2-low versus CSN2-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CSN2→partner) and Y-score (partner→CSN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Positive regulation of smoothened signaling pathway →	+0.064	+0.040	<.001	.003	2	8
TGCT	Oligodendrocyte differentiation →	+0.056	+0.047	<.001	<.001	3	7
TGCT	Positive regulation of neurogenesis →	+0.041	+0.076	<.001	<.001	3	7
TGCT	Negative regulation of canonical Wnt signaling pathway →	+0.081	+0.040	<.001	.003	3	7
TGCT	Anterior/posterior pattern specification →	+0.054	+0.071	<.001	<.001	3	7
LAML	Regulation of neuroblast proliferation →	+0.095	+0.013	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,213 associations by consensus.

Positive regulation of smoothened signaling pathway by CSN2 expression — TGCT

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