CSN2

Across TCGA patient cohorts, CSN2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSN2-associated genes across cancer lineages are EGFR_pY1068, MSH6, and STAT5a. Each is linked with CSN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSN2-to-partner and partner-to-CSN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CSN2-low versus CSN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSN2→partner) and Y-score (partner→CSN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.276	-3.169	.036	.019	3	1
UCEC	MSH6 →	-0.455	-3.321	.008	.010	3	1
UCEC	STAT5a →	+0.478	+3.169	.022	.019	3	1
UCEC	TIGAR →	+0.179	+2.196	.025	.034	3	1
UCEC	Caspase-7-cleavedD198 →	+0.659	+2.827	.034	.035	3	1
UCEC	Tuberin →	+0.387	+3.321	.006	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by CSN2 expression — UCEC

Explore this box plot interactively →