CSN1S2AP

Across TCGA pan-cancer cohorts, CSN1S2AP RNA is linked to patient survival in 7 of 34 cancer types, making it the most broadly survival-associated CSN1S2AP data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher CSN1S2AP RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CSN1S2AP expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

UVM, ACC, and SKCM are the cancer types where CSN1S2AP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.352	0.758	<.001	107	view →
ACC	OS	Tertile	All	0.523	0.831	<.001	75	view →
SKCM	DFS	Tertile	All	0.734	0.596	.002	45	view →
KIRP	OS	Tertile	II,III,IV	0.161	0.771	.002	45	view →
STAD	OS	Tertile	All	0.595	0.763	.038	27	view →
THCA	OS	Tertile	II,III,IV	0.178	0.904	<.001	21	view →
PRAD	OS	Tertile	All	0.913	0.996	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CSN1S2AP–UVM (DFS)

Open the UVM breakdown →