Across TCGA patient cohorts, CSH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,663 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible CSH2-associated GO terms across cancer lineages are Positive regulation of cell cycle G2/M phase transition, Formation of extrachromosomal circular DNA, and Positive regulation of cytokinesis. Each is linked with CSH2 in more than 12 cancer types. Because this analysis shows association rather than direction, both CSH2-to-partner and partner-to-CSH2 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CSH2→partner) and Y-score (partner→CSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Positive regulation of cell cycle G2/M phase transition →	+0.045	+0.078	<.001	<.001	3	13
SCLC	Formation of extrachromosomal circular DNA →	+0.103	+0.273	<.001	.009	2	13
STAD	Positive regulation of cytokinesis →	+0.074	+0.055	<.001	<.001	2	13
LIHC	Negative regulation of DNA-templated transcription, elongation →	+0.043	+0.015	<.001	<.001	3	12
TGCT	Actomyosin contractile ring organization →	+0.071	+0.908	<.001	<.001	3	12
HNSC	Positive regulation of DNA replication →	+0.045	+0.077	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,663 associations by consensus.

Exploration

CSH2 survival (RNA) · tumor vs normal (RNA) · all CSH2 data types