Across TCGA patient cohorts, CSH2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSH2-associated genes across cancer lineages are MSH2, MSH6, and mTOR_pS2448. Each is linked with CSH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSH2-to-partner and partner-to-CSH2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSH2→partner) and Y-score (partner→CSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.318	-2.459	.004	.020	3	1
UCEC	MSH6 →	-0.473	-2.999	.003	.035	3	1
UCEC	mTOR_pS2448 →	-0.149	-2.986	.038	.035	3	1
UCEC	Notch1 →	+0.255	+3.335	<.001	.005	3	1
UCEC	Shc_pY317 →	-0.160	-3.000	.029	.036	3	1
SKCM	Smac →	+0.304	+2.602	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

CSH2 survival (RNA) · tumor vs normal (RNA) · all CSH2 data types