Across TCGA cell cohorts, CSH2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CSH2-associated genes across cancer lineages are PRM2, CRYGC, and CALHM4. Each is linked with CSH2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSH2-to-partner and partner-to-CSH2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSH2→partner) and Y-score (partner→CSH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRM2 →	+0.042	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CRYGC →	+0.044	+4.969	<.001	.003	3	1
BLOOD_Leukemia	CALHM4 →	+0.019	+5.269	.004	<.001	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.092	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Exploration

CSH2 survival (RNA) · tumor vs normal (RNA) · all CSH2 data types