CSH1

Across TCGA pan-cancer cohorts, CSH1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CSH1 data layer compared with 7 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CSH1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CSH1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, STAD, and LUSC are the cancer types where CSH1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.629	.025	22	view →
STAD	OS	Median	All	0.098	0.539	.008	18	view →
LUSC	DFS	Median	III,IV	0.093	0.641	<.001	15	view →
HNSC	OS	Median	IV	0.176	0.639	.040	3	view →
SKCM	DFS	Median	III,IV	1.000	0.467	.027	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CSH1–UCEC (DFS)

Open the UCEC breakdown →