CSH1

Across TCGA patient cohorts, CSH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,412 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible CSH1-associated GO terms across cancer lineages are Cell cycle DNA replication, Positive regulation of cell cycle phase transition, and Positive regulation of cell cycle checkpoint. Each is linked with CSH1 in more than 5 cancer types. Because this analysis shows association rather than direction, both CSH1-to-partner and partner-to-CSH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle DNA replication grouped by CSH1-low versus CSH1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CSH1→partner) and Y-score (partner→CSH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cell cycle DNA replication →	+0.113	+0.030	<.001	<.001	2	5
HNSC	Positive regulation of cell cycle phase transition →	+0.032	+0.011	<.001	.002	3	4
STAD	Positive regulation of cell cycle checkpoint →	+0.111	+0.037	<.001	.003	2	5
STAD	Mitotic DNA replication →	+0.107	+0.029	<.001	<.001	1	6
STAD	Regulation of cyclin-dependent protein kinase activity →	+0.105	+0.036	<.001	.005	2	5
STAD	Mitotic sister chromatid segregation →	+0.137	+0.045	<.001	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,412 associations by consensus.

Cell cycle DNA replication by CSH1 expression — STAD

Explore this box plot interactively →